产品货号：
Z35792
中文名称：
NOTCH1抗体
英文名称：
Anti-NOTCH1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NOTCH1 Antibody |
| 指标别名 | hN1;Notch 1;NOTCH1;TAN1 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | NOTCH1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human Notch1 Functions as a receptor for membrane-bound ligands Jagged1,Jagged2 and Delta1 to regulate cell-fate determination.Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.Affects the implementation of differentiation,proliferation and apoptotic programs.Involved in angiogenesis;negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. |
| 实际分子量 | 125KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development.The Notch family includes 4 receptors,NOTCH1,NOTCH2,NOTCH3,and NOTCH4,whose ligands include JAG1,JAG2,DLL1),DLL3,and DLL4.Notch homolog 1,translocation-associated(NOTCH1),is a human gene encoding a single-pass transmembrane receptor.It functions as a receptor for membrane bound ligands,and may play multiple roles during development.NOTCH1 may normally coordinates the process of somitogenesis,and the activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia. |
| Uniprot ID | P46531 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～200 Flow cytometry (FCM) 1:50 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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